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. 2019 Feb 8;50:10. doi: 10.1186/s13567-019-0628-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Representative histopathological images (A–F) and immunohistochemistry (IHC) stainings (G–H) of caprine respiratory tissues. Tissues are derived from goats experimentally infected with Mycoplasma capricolum subsp. capripneumoniae (C–F) and from a mock-infected control group (A, B no histopathological lesions present). C, D Lesions of the acute form of contagious caprine pleuropneumonia; airways filled with neutrophilic granulocytes (asterisk), edema, hemorrhage and fibrinoid degeneration and necrosis of vascular wall (arrow). E, F Lesions of the chronic form of CCPP; abscess formation with central coagulative necrosis and fibrous encapsulation (arrow) and the beginning of bronchiolitis obliterans in a bronchiole (clover). G Mycoplasma capricolum subsp. capripneumoniae-positive IHC staining on apical cell border of ciliated respiratory epithelial cells in the trachea. H Mycoplasma capricolum subsp. capripneumoniae-positive IHC staining in alveoli associated with neutrophilic granulocytes infiltration. Size standards are displayed in the lower right corner of each picture: A = 1 mm; B = 200 µm, C = 200 µm, D = 50 µm, E = 1 mm; F = 100 µm; G + H = 20 µm.