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. 2019 Feb 8;38:63. doi: 10.1186/s13046-019-1072-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Human colon cancer cells are sensitive to GP130 inhibition. a: The expression of GP130, IL-11, IL-11Rα, IL-6, IL-6R, p-STAT3(Y705) and ER-α was evaluated in colon cancer cells. DLD-1, HCT-116, and HCT-15 cells were harvested, and the protein expression was detected by western blot. GAPDH served as a loading control. b: 5000 cells per well of DLD-1, HCT-15 and HCT-116 cells were seeded in 96-well plates and treated with neutralized GP130 antibody at 50 ng/ml in 2% FBS medium for 48 h. The IgG antibody at the same concentration served as a control. Cell viability was measured by MTT assay. (***, p < 0.001)