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. 2019 Feb 8;38:63. doi: 10.1186/s13046-019-1072-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Bazedoxifene inhibits colony formation and cell migration in human colon cancer cells. a: Colony formation assay was conducted in DLD-1, HCT-15, and HCT-116 cells as described in materials and methods. DLD-1, HCT-15, and HCT-116 cells were treated with bazedoxifene at indicated concentrations for 24 h, re-seeded at 1000 cells per well and cultured for 2–3 weeks to grow clones. b: A representative picture shows DLD-1 cells in a wound-healing assay. It was conducted by scratching the cells with a yellow pipette tip when DLD-1 cells grew into a monolayer. Then, cells were treated with bazedoxifene (15, 20 and/or 25 μM) and allowed to migrate into the scratched area for 24 h. Red arrows indicate a gap in the scratched area. c: The percentage of migrating area in wound-healing assay was quantified in DLD-1, HCT-15, and HCT-116 cells. (*, p < 0.05; **, p < 0.01; ***, p < 0.001)