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. 2019 Feb 8;38:63. doi: 10.1186/s13046-019-1072-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Bazedoxifene inhibits STAT3, AKT and ERK phosphorylation and downregulates expression of STAT3 downstream proteins. DLD-1, HCT-15, and HCT-116 human colon cancer cells were treated with different concentrations of bazedoxifene (10~35 μM) for 24 to 48 h. The protein expression of p-STAT3^Y705, p-AKT^S473, p-ERK1/2^T202/Y204, BCL-XL, cyclin D1, survivin, c-myc, ERK, AKT and STAT3 were detected by western blots with GAPDH as a loading control