Table 2. Frequency of HMT copy number alterations and mutations (%).
| Gene | Gene location | Amp | Gain | Diploid | Hetloss | Homdel | Mutation |
|---|---|---|---|---|---|---|---|
| NSD1 | 5q35.2 | 16.67 | 46.21 | 35.98 | 1.14 | 0.00 | 2.82 |
| PRDM6 | 5q23.2 | 13.45 | 44.13 | 41.10 | 1.33 | 0.00 | 0.00 |
| MECOM | 3q26.2 | 1.70 | 14.58 | 71.59 | 12.12 | 0.00 | 0.94 |
| KMT2C | 7q36.1 | 1.14 | 32.20 | 65.53 | 1.14 | 0.00 | 6.10 |
| EZH2 | 7q36.1 | 0.95 | 32.20 | 65.72 | 1.14 | 0.00 | 0.47 |
| PRDM14 | 8q13.3 | 0.57 | 12.12 | 74.43 | 12.88 | 0.00 | 0.47 |
| KMT2E | 7q22.3 | 0.57 | 32.58 | 66.67 | 0.19 | 0.00 | 1.41 |
| SETDB1 | 1q21.3 | 0.38 | 11.55 | 81.82 | 6.25 | 0.00 | 0.94 |
| ASH1L | 1q22 | 0.38 | 11.74 | 81.44 | 6.44 | 0.00 | 0.94 |
| SETD1A | 16p11.2 | 0.38 | 20.08 | 77.27 | 2.27 | 0.00 | 0.47 |
| KMT2A | 11q23.3 | 0.38 | 5.87 | 89.02 | 4.73 | 0.00 | 1.88 |
| PRDM11 | 11p11.2 | 0.19 | 6.26 | 90.51 | 3.04 | 0.00 | 0.47 |
| SMYD3 | 1q44 | 0.19 | 10.80 | 81.06 | 7.95 | 0.00 | 0.00 |
| WHSC1L1 | 8p11.23 | 0.19 | 5.68 | 68.75 | 24.62 | 0.76 | 2.82 |
| SMYD2 | 1q32.3 | 0.19 | 10.98 | 81.25 | 7.58 | 0.00 | 0.47 |
| PRDM1 | 6q21 | 0.19 | 1.52 | 71.59 | 26.52 | 0.19 | 0.47 |
| SUV39H2 | 10p13 | 0.19 | 3.22 | 84.09 | 12.31 | 0.19 | 0.00 |
| PRDM9 | 5p14.2 | 0.19 | 32.01 | 66.86 | 0.95 | 0.00 | 0.47 |
| EZH1 | 17q21.2 | 0.19 | 5.68 | 88.45 | 5.68 | 0.00 | 0.47 |
| SUV39H1 | Xp11.23 | 0.19 | 5.49 | 85.42 | 8.52 | 0.38 | 0.00 |
| PRDM7 | 16q24.3 | 0.19 | 18.56 | 77.08 | 4.17 | 0.00 | 0.47 |
| EHMT1 | 9q34.3 | 0.19 | 2.84 | 67.61 | 28.98 | 0.38 | 0.94 |
| PRDM10 | 11q24.3 | 0.19 | 5.49 | 88.83 | 4.92 | 0.57 | 0.00 |
| PRDM5 | 4q27 | 0.19 | 2.08 | 83.33 | 14.20 | 0.19 | 0.47 |
| DOT1L | 19p13.3 | 0.19 | 8.71 | 87.50 | 3.22 | 0.38 | 0.94 |
| SETD7 | 4q31.1 | 0.19 | 2.65 | 82.95 | 14.02 | 0.19 | 0.00 |
| SMYD4 | 17p13.3 | 0.19 | 5.11 | 85.61 | 9.09 | 0.00 | 0.94 |
| SETDB2 | 13q14.2 | 0.19 | 3.98 | 80.49 | 15.15 | 0.19 | 0.00 |
| SUV420H1 | 11q13.2 | 0.00 | 6.25 | 90.15 | 3.60 | 0.00 | 1.41 |
| SUV420H2 | 11q13.2 | 0.00 | 10.80 | 88.07 | 0.95 | 0.19 | 0.47 |
| SETMAR | 3p26.1 | 0.00 | 1.33 | 12.31 | 76.33 | 10.04 | 0.47 |
| SETD5 | 3p25.3 | 0.00 | 1.33 | 11.17 | 77.08 | 10.42 | 0.94 |
| EHMT2 | 6p21.31 | 0.00 | 1.89 | 79.17 | 18.94 | 0.00 | 1.41 |
| PRDM13 | 6q16.2 | 0.00 | 1.52 | 71.78 | 26.52 | 0.19 | 0.94 |
| PRDM15 | 21q22.3 | 0.00 | 9.66 | 79.55 | 10.42 | 0.38 | 0.47 |
| PRDM16 | 1p36.32 | 0.00 | 1.70 | 79.36 | 18.94 | 0.00 | 0.47 |
| SETD4 | 21q22.12 | 0.00 | 9.66 | 80.11 | 10.23 | 0.00 | 0.00 |
| SETD8 | 12q24.31 | 0.00 | 22.92 | 75.95 | 1.14 | 0.00 | 0.47 |
| PRDM12 | 9q34.12 | 0.00 | 2.46 | 68.37 | 28.98 | 0.19 | 0.00 |
| PRDM8 | 4q21.21 | 0.00 | 2.46 | 85.04 | 12.50 | 0.00 | 0.00 |
| SETD1B | 12q24.31 | 0.00 | 22.92 | 75.95 | 1.14 | 0.00 | 0.00 |
| SETD3 | 14q32.2 | 0.00 | 2.84 | 53.60 | 43.18 | 0.38 | 1.41 |
| WHSC1 | 4p16.3 | 0.00 | 2.84 | 83.90 | 13.26 | 0.00 | 1.88 |
| KMT2D | 12q13.12 | 0.00 | 22.73 | 76.33 | 0.95 | 0.00 | 1.41 |
| PRDM4 | 12q23.3 | 0.00 | 22.92 | 75.95 | 1.14 | 0.00 | 0.00 |
| SETD6 | 16q21 | 0.00 | 18.56 | 77.27 | 4.17 | 0.00 | 0.00 |
| SMYD5 | 2p13.2 | 0.00 | 14.39 | 82.95 | 2.65 | 0.00 | 0.00 |
| PRDM2 | 1p36.21 | 0.00 | 1.33 | 79.92 | 18.75 | 0.00 | 0.47 |
| SMYD1 | 2p11.2 | 0.00 | 14.39 | 83.14 | 2.46 | 0.00 | 0.00 |
| SETD2 | 3p21.31 | 0.00 | 1.14 | 10.80 | 77.27 | 10.80 | 11.51 |
Notes:
Amp = high-level amplification; Gain = low-level gain; Hetless = heterozygous deletion; Homdel = homozygous deletion.
Genes were ranked based on the frequency of high-level amplification.