Table 2.
Clinical outcomes at 14 days or hospital discharge according to baseline systolic blood pressure levels.
| Outcome variables | <160 mm Hg | 160-179 mm Hg | ≥180 mm Hg | P value for homogeneity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment (n=715) | Control (n=765) | OR (95% CI) | P value | Treatment (n=838) | Control (n=851) | OR (95% CI) | P value | Treatment (n=478) | Control (n=411) | OR (95% CI) | P value | ||
| Primary outcome | |||||||||||||
| Death or major disabilitya, n (%) | 225 (31.5) | 228 (29.8) | 1.08 (0.87 to 1.35) | 0.49 | 288 (34.4) | 297 (34.9) | 0.98 (0.80 to 1.19) | 0.82 | 170 (35.6) | 156 (38.0) | 0.90 (0.69 to 1.19) | 0.46 | 0.29 |
| Secondary outcomes | |||||||||||||
| Score on modified Rankin scaleb, median (IQR) | 2.0 (1.0-3.0) | 2.0 (1.0-3.0) | 0.34 | 2.0 (1.0-3.0) | 2.0 (1.0-3.0) | 0.47 | 2.0 (1.0-3.0) | 2.0 (1.0-3.0) | 0.25 | 0.12 | |||
| Participants, n (%) | |||||||||||||
| 0 (no symptoms) | 66 (9.2) | 55 (7.2) | 1.09 (0.91 to 1.31)c | 0.34 | 93 (11.1) | 70 (8.2) | 0.94 (0.79 to 1.11) c | 0.47 | 45 (9.4) | 29 (7.1) | 0.87 (0.69 to 1.10) c | 0.25 | 0.29 |
| 1 (no significant disability despite symptoms) | 228 (31.9) | 287 (37.5) | 266 (31.7) | 278 (32.7) | 159 (33.3) | 136 (33.1) | |||||||
| 2 (slight disability) | 196 (27.4) | 195 (25.5) | 191 (22.8) | 206 (24.2) | 104 (21.8) | 90 (21.9) | |||||||
| 3 (moderate disability) | 97 (13.6) | 110 (14.4) | 120 (14.3) | 129 (15.2) | 75 (15.7) | 58 (14.1) | |||||||
| 4 (moderately severe disability) | 88 (12.3) | 81 (10.6) | 110 (13.1) | 129 (15.2) | 60 (12.6) | 72 (17.5) | |||||||
| 5 (severe disability) | 31 (4.3) | 33 (4.3) | 46 (5.5) | 28 (3.3) | 31 (6.5) | 16 (3.9) | |||||||
| 6 (dead) | 9 (1.3) | 4 (0.5) | 12 (1.4) | 11 (1.3) | 4 (0.8) | 10 (2.4) | |||||||
| Death, n (%) | 9 (1.3) | 4 (0.5) | 2.42 (0.74 to 7.89) | 0.14 | 12 (1.4) | 11 (1.3) | 1.11 (0.49 to 2.53) | 0.80 | 4 (0.8) | 10 (2.4) | 0.34 (0.11 to 1.09) | 0.07 | 0.02 |
| Duration of initial hospitalization, median (IQR), days | 12.0 (9.0-14.0) | 13.0 (9.0-14.0) | 0.94 | 13.0 (9.0-14.0) | 13.0 (9.0-14.0) | 0.13 | 13.0 (9.0-14.0) | 13.0 (9.0-14.0) | 0.99 | 0.82 | |||
Difference in the percentages of composite death or major disability and all-cause mortality between the antihypertensive treatment and control groups was tested using a χ2 test, the medians of Rankin score and hospitalization using the Wilcoxon rank-sum test, and odds ratios of ordinal Rankin scores using ordinal logistic regression.
a
Modified Rankin Score of 3 or greater.
b
Scores on the modified Rankin Scale, for which a score of 0 indicates no symptoms, a score of 5 indicates severe disability, and a score of 6 indicates death.
c
Odds of a 1-unit higher modified Rankin score.