Table 1.
Sample Background and Neuropathology characteristics
|
Entire Sample (N=1383) |
APOE carrier status | |||
|---|---|---|---|---|
| ε4+ (n=342) |
ε2+ (n=180) |
ε3/ε3 (n=861) |
||
| Background | ||||
| Age at death (yrs) | 88.85 ±6.78 |
87.71 ±6.54 |
89.91 ±7.20 |
89.08 ±6.73 |
| Sex (M:F) | 458:925 | 115:227 | 53:127 | 290:571 |
| Race (W:B:O) | 1329:49:4 | 321:20:1 | 173:6:1 | 835:23:2 |
| Education (yrs) | 16.25 ±3.63 |
16.75 ±3.58 |
15.74 ±3.31 |
16.16 ±3.70 |
| MMSE at death | 20.81 ±9.25 |
17.57 ±10.35 |
22.62 ±8.21 |
21.73 ±8.67 |
| MCI at death (%) | 23.80 | 19.35 | 22.22 | 26.00 |
| Demented at death (%) | 43.60 | 60.11 | 33.33 | 39.25 |
| Neuropathology | ||||
| Arteriolosclerosis (%) | 33.70 | 33.63 | 42.22 | 31.94 |
| Macroinfarcts (%) | 35.36 | 38.90 | 35.00 | 34.03 |
| Microinfarcts (%) | 30.01 | 29.82 | 31.67 | 29.73 |
| Atherosclerosis (%) | 34.20 | 35.10 | 37.78 | 33.10 |
| Global AD-related | 0.74 +0.62 |
1.11 +0.66 |
0.41 +0.42 |
0.66 +0.57 |
| CAA (% with moderate/severe) |
33.55 | 51.75 | 33.33 | 26.36 |
| NIA Reagan (%) | 63.85 | 81.87 | 46.11 | 60.40 |
Note: all values equal mean±standard deviation unless otherwise noted. Abbreviations: yrs=years; M=male, F=female; W=white, B=black, O=other including Native American and Asian/Pacific Island; MMSE=Mini-Mental State Examination; MCI=mild cognitive impairment; CAA=cerebral amyloid angiopathy; NIA Reagan=AD present by NIA Reagan Pathology criteria (High or Intermediate Likelihood); %=percent.