Figure 5. Distinction between functions of TAC-associated proteins and KSFs.

Early abnormal trypanosomes reported after knockdown of several proteins that affected kinetoplast cycle were analyzed as described (see Table 1 for summary). Genes were assigned to one of the five steps in kinetoplast biogenesis (see Figure 2), based on a comparison of published phenotypic data and the predicted of expected aberrant kinetoplasts (Table 1 and Figure 3).