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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Trends Parasitol. 2019 Jan 10;35(2):119–128. doi: 10.1016/j.pt.2018.11.002

Table 1.

Sets of unusual kinetoplast combinations predicted for classes of mutants

Category Stage in kinetoplast cycle Expected set of abnormal trypanosomes
Class I kDNA synthesis 1KS1N, KS/KS1N, KS/KS2N
Class II Selection of Scission Site KL/KS1N, KL/KS2N, 1KL1N, 1KS1N
Class III Scission of kDNA network 1KU1N, 1KU2N, 0K1N. Electron microscopy shows one uncleaved kDNA per kinetoplast
Class IV Separation of Cleaved kDNA networks 1KU1N, 1KU2N, 0K1N. Two cleaved kDNAs per kinetoplast, detected in electron microscopy analysis
Class V Partitioning of kinetoplasts into new cells 2K1N, 0K1N

Different types of kinetoplasts and the expected sets appearing together are presented for mutants belonging to classes I through V. Kinetoplast designations are as follows; K, kDNA containing one genomes’ worth of minicircles and maxicircles; KS, kinetoplast contains less < 0.5 of one genome’s equivalent of kDNA; KL, kinetoplast contains > 0.5 < 1 of one genome’s equivalent of kDNA; KU, kDNA has two genome’s amount of minicircles and maxicircles.