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Regulation of the synthesis and trafficking of lysosomal enzymes. TFEB modulates the expression of various lysosomal enzymes and of their transporters: LIMP-2 (SCARB2), sortilin (SORT1), and the mannose-6-phosphate (M6P) receptors (M6PR and IGF2R). TFEB also modulates the expression of a subunit of GlcNac-1-phosphotransferase (GNPTG) and of the uncovering enzyme (NAGPA), the Golgi-residing enzymes that generate the mannose-6-phosphate tags on most lysosomal enzymes.
