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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: Science. 2018 Oct 12;362(6411):176–180. doi: 10.1126/science.aas9435

Fig.1: Modes of division of neural progenitors. A. Neurogenesis in the primate cortex.

Fig.1:

aRG undergo symmetric cell divisions to expand their pool (proliferative phase), and then transit to a neurogenic phase where they generate neurons directly or indirectly through intermediate progenitors such as bIPs and oRGs. Changes in TF expression in progenitors over time are shown as changes in cell color. aRG: apical radial glia. bIP: basal intermediate progenitor. oRG: outer radial glia. GW: gestational week. B. Different modes of NB division in Drosophila. Type 0 NBs self-renew and generate a single neuron at each division. Type I NBs self-renew and produce GMCs that divide once to produce one NotchON and one NotchOFF neuron. Type II NBs have an increased neuronal output by generating INPs, which themselves asymmetrically divide multiple times to produce GMCs. Both NBs and INPs sequentially express series of tTFs as they age (examples of these and additional temporal factors in NBs are shown). Cas: Castor. D: Dichaete. Svp: Seven-up. Imp: IGF-II mRNA-binding protein. Chinmo: Chronologically inappropriate morphogenesis. Syp: Syncrip. EcR: ecdysone receptor. Br: Broad. E93: Eip93. Grh: Grainy head. Ey: Eyeless. hALH: hours after larval hatching. Modified after Doe et al., 2017 (3).