Skip to main content
. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: Science. 2018 Oct 12;362(6411):176–180. doi: 10.1126/science.aas9435

Fig. 3.: Spatial patterning of progenitors. A. Integration between spatial and temporal patterning in the Drosophila optic lobe. Left panel:

Fig. 3.:

Regionalization of the Drosophila optic lobe neuroepithelium (NE) by the expression of the TFs Optix, Vsx and Rx. Middle panel: Sequential expression of the tTFs Hth-Ey-Slp-D in optic lobe NBs of different ages. Right panel: Schematic of spatial and temporal factors acting in optic lobe NBs. The neuroepithelium is additionally patterned by the signaling molecules Dpp and Wg and by Hh in the ventral part, creating eight compartments along the dorsoventral axis. B. Morphogens spatially pattern the mammalian spinal cord and telencephalon. Left panel: Dorso-ventral patterning of the neural tube by Wnt/BMP and Shh that regulate the expression of TFs in progenitors, which produce different types of neurons. Early born neurons are different from those produced at later stages. The progenitor domains and the neurons generated in each one of them are indicated. NC: notochord. FP: floor plate. RF: roof plate. VZ: ventricular zone. MZ: mantle zone. Right panel: Schematic of the mouse embryonic telencephalon that is similarly patterned by the morphogens Wnt and BMPs from the dorsal hem and ventrally by the secretion of Shh. FGFs are secreted from a rostral signaling center (violet). GABAergic interneurons are generated from the lateral (LGE) and medial ganglionic eminences (MGE) in the ventral telencephalon and migrate tangentially to reach the cortex.