Table 5. Correlation of HIF-1α, MDR1, and LAPTM4B expression with clinico-pathological features of colon cancer.
| Clinical-pathological Characteristics | ALLN (%) | HIF-1α expression | MDR1 expression | LAPTM4B expression | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | p-value | Low | High | p-value | Low | High | p-value | |||
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||||||
| Age | 0.382 | 0.318 | 0.500 | ||||||||
| <50 | 20 (62.5) | 9 (45.0) | 11 (55.0) | 10 (50.0) | 10 (50.0) | 11 (55.0) | 9 (45.0) | ||||
| >50 | 12 (37.5) | 3 (25.0) | 9 (75.0) | 5 (41.6) | 7 (58.3) | 6 (50.0) | 6 (50.0) | ||||
| Stage | 0.016 | 0.005 | 0.007 | ||||||||
| I–II | 13 (40.6) | 7 (53.8) | 4 (30.7) | 7 (53.8) | 6 (46.1) | 9 (69.2) | 4 (30.8) | ||||
| III–IV | 19 (59.3) | 5 (26.3) | 16 (84.2) | 8 (42.1) | 11 (57.8) | 8 (42.1) | 11 (57.8) | ||||
| Metastasis | 0.045 | 0.024 | 0.055 | ||||||||
| Metastatic | 21 (65.6) | 7 (33.3) | 18 (85.7) | 8 (38.0) | 13 (61.9) | 8 (38.0) | 11 (52.4) | ||||
| Non-metastatic | 11 (34.3) | 5 (45.45) | 2 (18.2) | 7 (63.6) | 4 (36.3) | 9 (81.8) | 4 (36.4) | ||||
| Chemotherapy status | 0.001 | 0.049 | 0.007 | ||||||||
| Treatment naive | 13 (40.6) | 6 (46.1) | 7 (53.8) | 9 (69.2) | 4 (30.7) | 9 (69.2) | 4 (30.7) | ||||
| Pre-treated | 19 (59.3) | 6 (31.5) | 15 (78.9) | 6 (31.6) | 13 (68.4) | 8 (42.1) | 11 (57.8) | ||||
Notes:
The N shows the number of patients in each group. Where p value describes the significance and p < 0.05 shows the significance of results.