Figure 2.

(A) General design of macrocyclic β-sheet peptides, including the “recognition” β-strand, the “blocking” β-strand (with the Hao unit in blue), and the δ-linked ornithine turns (in green). (B) Sequence of hIAPP-labeled by its secondary structure. The black arrows indicate the β-sheet regions determined by ssNMR,¹⁴ while the light gray extension of the C-terminal arrow indicates residues that exhibit β-sheet-like coupling in 2D IR spectra. Sequences targeted by the recognition strand of the macrocycles are listed.