Fig. 2.
Mechanically-stimulated adenosine. A) Example mechanically-evoked adenosine in the hippocampus. Electrode was lowered 0.1 mm at 30 s (arrow). Concentration vs. time trace (top) shows adenosine peak concentration was 21 μM. B) Average data for four consecutive mechanical stimulations in the prefrontal cortex (PFC), striatum (STR), and hippocampus (HPC) in vivo. 4 consecutive stimulations were performed every 15 min. There was a significant effect of brain region on the concentration of mechanically-evoked release (two-way repeated measures ANOVA, p < 0.033). C) Average concentrations significantly vary by region (One-way ANOVA, p = 0.0005) and concentration in the hippocampus was significantly higher than in the prefrontal cortex and striatum (post hoc Tukey’s test, p = 0.012 and p = 0.0004, respectively). D) Mechanically-stimulated release concentration vs. spontaneous release concentration. There appears to be no correlation. E) Mechanically-stimulated concentration vs. number of spontaneous transients per hour. There appears to be no correlation. Error bars are SEM.