Table 1.
Comparison of demographic data, clinical, and laboratory findings between CLL patients and healthy controls
| Patients (n = 40) | Control (n = 40) | Test for sig. | |
|---|---|---|---|
| Sex | |||
| Male | 26 (65.0) | 21 (52.5) | ap = 0.256 |
| Female | 14 (35.0) | 19 (47.5) | |
| Age (years) | 58.40 ± 8.04 | 56.58 ± 8.74 | bp = 0.334 |
| HB g/dL | 11.21 ± 2.70 | 13.03 ± 0.77 | bp < 0.001* |
| WBC (× 103/µL) | 48.70 (10.23–844.80) | 6.73 (4.23–10.0) | cp < 0.001* |
| Platelets (× 103/µL) | 172.50 (12.0–521.0) | 295.0 (176.0–422.0) | cp < 0.001* |
| Absolute lymphocyte count (ALC) (× 103) | 38.484 (13.50–633.60) | 2.244 (1.269–3.50) | cp < 0.001* |
| BCL2 MFI-R | 1.72 ± 0.51 | 0.62 ± 0.14 | bp < 0.001* |
| ZAP-70% | |||
| ZAP-70− (< 20%) | 27 (67.5%) | 40 (100%) | ap < 0.001* |
| ZAP-70+ (≥ 20%) | 13 (32.5%) | 0 (0%) | |
| CD38% | ap < 0.001* | ||
| CD38− (< 20%) | 26 (65%) | 40 (100%) | |
| CD38+ (≥ 20%) | 14 (35%) | 0 (0%) | |
| Lymph nodes | |||
| Axillary and cervical | 14 (42.4%) | ||
| Cervical | 9 (27.3%) | ||
| Generalized | 7 (21.2%) | ||
| Inguinal | 2 (6.1%) | ||
| Paraaortic | 1 (3.0%) | ||
| Modified Rai stage | |||
| Low | 18 (45.0%) | ||
| Intermediate | 10 (25.0%) | ||
| High | 12 (30.0%) | ||
| Time to treatment (TTT) (months) | 6.5 (0.0–26.0) | ||
Normally distributed data was expressed as mean ± SD, while abnormally distributed data was expressed as medians (min–max)
*Statistically significant at p ≤ 0.05
ap: p value for Chi square test; bp: p value for Student’s t-test; cp: p value for Mann–Whitney test