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. 2018 Dec 31;12:173–194. doi: 10.1016/j.omto.2018.12.011

Figure 1.

Figure 1

Schematic Representation of the miR-29 Family Members: miR-29a, -29b, and -29c

miR-29 family members have identical seed sequences (orange box and underlined) along with similar mature miRNA sequences. However, notable differences in nucleotides are indicated in red. Tri-uracil nucleotides at positions 9–11 nt (blue box) present in miR-29b and -29c contribute to instability and shorter half-life, and the hexanucleotide sequence at positions 18–23 nt (green box) is unique to miR-29b, leading to nuclear localization.