Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;10:33. doi: 10.3389/fphar.2019.00033

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Vasconcelos, dos Santos, Scavone and Munhoz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The role of NRF2 and dietary interventions (DER and HFD) on the modification of the BBB. Neurological diseases, such as AD, PD, MS, and ischemic stroke, can lead to BBB disruption. However, Nrf2 protects neurons and the BBB against oxidative stress and inflammation-induced damage. Astrocytes, microglia and neurons produce Nrf2 that activates the expression of antioxidant and anti-inflammatory genes to the maintenance of neuronal health and BBB integrity. Nrf2 protective effects on BBB can be modulated by DER and HFD, modifying the release of inflammatory mediators by glial cells in neurodegenerative diseases. Green arrows represent activation and truncated red lines, inhibition (abbreviations: BBB, blood-brain barrier; DER, dietary energy restriction; HFD, high-fat diet, MS, multiple sclerosis; PD, Parkinson’s disease; DER, dietary energy restriction; HFD, high-fat diet).