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. 2019 Feb 4;10:63. doi: 10.3389/fimmu.2019.00063

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Copyright © 2019 Li, Teteloshvili, Tan, Rao, Han, Yang and Creusot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MART1 peptide expression leads to a profound deletion of specific T cells. (A,B) Percentage of Tet⁺ cells in human CD8⁺ T cells (A) and CD4⁺ T cells (B) in the peripheral blood at different time points after HSC and thymic graft transplantation (mean ± SEM; peptide n = 8, control n = 9). (C–E) Percentage of Tet⁺ cells in different thymocyte populations (C), and in CD8⁺ T cells (D) and CD4⁺ T cells (E) from peripheral tissues and blood at end point (mean ± SEM, peptide n = 8, control n = 8). All panels: filled and open circles depict mice from Peptide and Control groups, respectively.