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. 2019 Feb 4;10:85. doi: 10.3389/fimmu.2019.00085

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Copyright © 2019 Mussbacher, Salzmann, Brostjan, Hoesel, Schoergenhofer, Datler, Hohensinner, Basílio, Petzelbauer, Assinger and Schmid.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NF-κB and IκB family of proteins and their functional domains. The proteins are designated by their gene symbols with frequently used aliases in brackets. RHD, Rel-homology domain, responsible for DNA binding and dimerization; TA, transactivation domain, responsible for binding of the transcriptional machinery and RNA-polymerase; LZ, leucine zipper; NLS, nuclear localization domain; A, ankyrin repeat; DD, death domain; PP, double-phosphorylation by IκB kinases triggering ubiquitination and proteasomal degradation or processing (in case of NFKB1 and NFKB2). The numbers specify the amino acid borders of domains for human isoforms. Atypical inhibitors are described in more detail in Pettersen et al. (13).