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. 2018 Oct 24;7(2):411–431. doi: 10.1016/j.jcmgh.2018.10.011

Table 5.

Biological Functions (GO Analysis) Associated With Differentially Methylated Genes in RRBS at Early Passage (p8)

Biological functions P value Genes, n
Hypermethylated
 Neuronal system 7.21E-14 73
 Regulation of membrane potential 1.04E-06 60
 Behavior 1.24E-06 77
 Regulation of heart contraction 6.91E-05 37
 Muscle contraction 9.72E-05 48
 Cellular potassium ion transport 1.76E-04 31
 Midgut development 8.59E-04 5
 Neuromuscular process 2.58E-03 21
 Smooth muscle contraction 3.42E-03 3
Hypomethylated
 Embryonic morphogenesis 7.81E-06 15
 Heart morphogenesis 3.24E-05 9
 Cardiovascular system development 1.41E-04 15
 Heart looping 6.29E-04 4
 Embryonic heart tube development 1.63E-03 3
 Regulation of developmental growth 4.80E-03 7
 Negative regulation of MAPK cascade 5.78E-03 5
 Actin filament-based process 6.78E-03 11