Table 5.
Biological Functions (GO Analysis) Associated With Differentially Methylated Genes in RRBS at Early Passage (p8)
| Biological functions | P value | Genes, n |
|---|---|---|
| Hypermethylated | ||
| Neuronal system | 7.21E-14 | 73 |
| Regulation of membrane potential | 1.04E-06 | 60 |
| Behavior | 1.24E-06 | 77 |
| Regulation of heart contraction | 6.91E-05 | 37 |
| Muscle contraction | 9.72E-05 | 48 |
| Cellular potassium ion transport | 1.76E-04 | 31 |
| Midgut development | 8.59E-04 | 5 |
| Neuromuscular process | 2.58E-03 | 21 |
| Smooth muscle contraction | 3.42E-03 | 3 |
| Hypomethylated | ||
| Embryonic morphogenesis | 7.81E-06 | 15 |
| Heart morphogenesis | 3.24E-05 | 9 |
| Cardiovascular system development | 1.41E-04 | 15 |
| Heart looping | 6.29E-04 | 4 |
| Embryonic heart tube development | 1.63E-03 | 3 |
| Regulation of developmental growth | 4.80E-03 | 7 |
| Negative regulation of MAPK cascade | 5.78E-03 | 5 |
| Actin filament-based process | 6.78E-03 | 11 |