Table 6.
Biological Functions (GO Analysis) Associated With Differentially Methylated Genes in RRBS at Late Passage (p14)
| Biological functions | P value | Genes, n |
|---|---|---|
| Hypermethylated | ||
| Neuronal system | 4.82E-06 | 39 |
| Cardiac conduction | 2.49E-05 | 20 |
| Muscle contraction | 6.85E-05 | 24 |
| Behavior | 3.19E-04 | 47 |
| Regulation of membrane potential | 4.19E-04 | 36 |
| Cellular potassium ion transport | 8.25E-04 | 21 |
| Midgut development | 1.39E-03 | 4 |
| Actin filament-based process | 1.39E-03 | 50 |
| Hindgut development | 5.34E-03 | 3 |
| Hypomethylated | ||
| Embryonic morphogenesis | 4.52E-04 | 12 |
| Regulation of embryonic development | 1.33E-03 | 5 |
| Regulation of cellular response to stress | 1.38E-03 | 12 |
| Chromatin organization | 2.23E-03 | 7 |
| Negative regulation of response to wounding | 2.24E-03 | 4 |
| Heart morphogenesis | 4.98E-03 | 6 |
| Pathway-restricted SMAD phosphorylation | 2.47E-03 | 3 |
| Muscle structure development | 9.26E-03 | 10 |
SMAD, Mothers Against Decapentaplegic Homolog.