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. 2019 Jan 25;13:167–179. doi: 10.1016/j.omtm.2019.01.007

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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AAV9-TAZ Administration Improves Aberrant Protein Expression Profiles

(A) Volcano plots of log2 fold change ratios of proteins from healthy WT (black), AAV9-TAZAd-treated (green), and AAV9-TAZNeo-treated (blue) heart lysate samples as compared to untreated BTHS. (B) The AAV9-TAZAd-treated profile is very similar to that of healthy WT controls. (C) The AAV9-TAZNeo-treated profile shows the overall highest expression levels. (D) A Venn diagram showing the total numbers of proteins found to be differentially expressed in BTHS that display significant improvement in expression levels in the treated groups.