Figure 3.

Histological Analysis of Homing Peptide Binding to Tumor, Liver, and Kidney Tissues in SCID Mice Bearing LNCaP Cell Xenografts

Tumor, liver, and kidney tissues were excised after each tumor-targeting peptide was administered to the tumor-implanted mouse, and DAB staining was performed. Control peptide was detected in tumor tissue and also in liver and kidney tissue. Binding of LN3 peptide was observed in tumor and kidney tissues. In contrast, LN1 and LN2 peptides were found in tumor tissue only. Arrowheads show positive staining of DAB. Scale bars, 100 μm.