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. 2019 Jan 8;13:180–186. doi: 10.1016/j.omtm.2018.12.012

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© 2019 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

rAAV8-GAD67 Attenuates Seizure Sensitivity in EL Mice

Four weeks after delivery of rAAV8-GAD67, a remarkable reduction in the progression of seizures was observed. Severity was obtained by the following calculation: (2.0 × number of the mouse, which indicated score 2 + 1.0 × number of the mouse, which indicated score 1) ÷ total number of the mouse by each group. For instance, when 3 mice show tonic-clonic convulsion and 4 mice show head nodding or tail stiffening, epilepsy intensity can be calculated with 1.43: (2.0 × 3 + 1.0 × 4) ÷ 7 = 1.43.8, p < 0.05 relative to delivery of rAAV8-GAD67; 6, p < 0.01 relative to delivery of rAAV8-GAD67.