Table 1.
Structural, functional, and substrate interaction properties of the ERdj family
The following abbreviations are used: M, membrane; L, lumen; NB, nonbinder of nascent secretory protein substrate; NA, not applicable.
| Protein size | DnaJ classification | ER location | Substrate-binding domain | In vivo sequence-binding profilea | Secretory protein processing role | |
|---|---|---|---|---|---|---|
| kDa | ||||||
| ERdj1 | 63.9 | Type III | M | NB | NA | Translation regulator |
| ERdj2 | 88.0 | Type III | M | NB | NA | Translocation regulator |
| ERdj3 | 40.5 | Type I | L | Domain I | Diverse sequences | Pro-folding or ERAD? |
| ERdj4 | 25.5 | Type II | L | Trx 1–4 | Aggregation-prone | ERAD, UPR regulator |
| ERdj5 | 91.0 | Type III | L | SBD | Aggregation-prone | Disulfide reductase, pro-folding, ERAD |
| ERdj6 | 57.6 | Type III | L | TPR-1 | Untested | Pro-folding? |
| ERdj7 | 42.4 | Type III | M | NB | NA | Unknown |
a In vivo binding profiles have been assessed with immunoglobulin substrates (62).