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Proposed pathway of Tyr residue oxidation in cyt c protein leading to the autogeneration of TPQ followed by Lys residue deamination to aminoadipic semialdehyde. Insets demonstrate results of MS/MS-based identification of corresponding modifications on Tyr-48, -67, -74, and -97 residues of cyt c in the absence (columns 1–3, blue), or presence of H2O2 (columns 4 and 5, red), TLCL (columns 6–8, yellow) or combination of both (columns 9 and 10, orange). diTyr, dityrosine cross-links.
