Figure 1.

Diversity of PPIs between molecular chaperones. Representative structures of PPIs between chaperones are shown. Hsp70 refers to the nucleotide-binding domain of either the prokaryotic or eukaryotic protein, and ACD is the α-crystallin domain of a small heat shock protein. Monomers of Hsp60 are shown in blue and orange. Please see the citations and PDB codes for information on the exact constructs used: Hsp70-J domain (5NRO); Hsp70–BAG (1HX1); TPR–EEVD (4KBQ); Hsp90–Aha1 (1USU); Hsp90–p23 (2CG9); Hsp90–Cdc37–Cdk4 (5FWP); Hsp60–Hsp10 (4PJ1); TRiC (5GW4); α-crystallin ACD–ACD (2WJ7); and Hsp27 ACD–IPV (4MJH).