Table 3.
Results of subgroup analysis of randomized controlled trials included in this meta-analysis of the effect of L-citrulline supplementation on blood pressure
| Variable | Mean age | Dose of supplementation | Trial duration | |||
|---|---|---|---|---|---|---|
| SBP | > 55 years | 20-25 years | ≥ 6 g/day | < 6 g/day | ≥ 4 weeks | < 4 weeks |
| No. of comparison | 4 | 6 | 2 | 8 | 5 | 5 |
| WMD (95% CI) | -4.709 (-7.940, 2.243) |
-3.761 (-8.273, 0.752) |
-6.141 (-15.647, 3.366) |
-3.505 8.013, 1.003)) |
-4.125 (-9.145, 0.895) |
-4.240 (-10.723, 2.244) |
| p value | 0.184 | 0.102 | 0.206 | 0.127 | 0.107 | 0.200 |
| I 2 (%) | 87 | 51.6 | 76.9 | 75.3 | 70.2 | 78.3 |
| p-heterogeneity | >0.001 | 0.066 | 0.038 | > 0.001 | 0.009 | 0.001 |
| DBP | ||||||
| No. of comparison | 4 | 6 | 2 | 8 | 5 | 5 |
| WMD (95% CI) | -3.664 (-4.315 , 0.164) |
-0.702 (-2.728, 1.325) |
0.111 (-3.158, 3.380) |
-2.750 (-5.372, -0.128) |
-3.057 (-6.802, 0.688) |
-0.765 (-2.824 , 1.294) |
| p value | 0.080 | 0.497 | 0.947 | 0.040 | 0.11 | 0.466 |
| I 2 (%) | 5.8 | 76.1 | 21.3 | 62.4 | ||
| p-heterogeneity | 0.362 | 0.006 | 0.260 | 0.010 | ||
CI, confidence interval; WMD, weighted mean differences, SBP, systolic blood pressure, DBP, diastolic blood pressure