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Schematic of TNF signaling via its two receptors TNFR1 and TNFR2 as well as the existing potential therapeutic approaches targeting TNFR2, including solTNF inhibitor [e.g., xPro1595 (Olleros et al., 2010; Shi et al., 2011a)], TNFR1-specific antagonist [e.g., ATROSAB (Kim et al., 2016)], and TNFR2-specific agonists [e.g., TNF-scTNFR2 (Fischer et al., 2011) and EHD2-scTNFR2 (Dong et al., 2016)]. solTNF, soluble tumor necrosis factor; tmTNF, transmembrane tumor necrosis factor.
