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FGD1 silencing causes an increase in PAK1 and IQGAP1 expression levels. HeLa cells were silenced with FGD1-specific siRNA for 72 h, subsequently lysed, subjected to SDS–PAGE and labeled with antibodies of interest. (A) Immunoblots of FGD1, IQGAP1, and PAK1 in both control and FGD1-silenced cells. (B,C) Quantification showing the increase in IQGAP1 (B) and PAK1 (C) levels in FGD1-deficient cells (n = 3 experiments; ∗∗∗p < 0.001, ∗p < 0.005, t-test).
