Table 2.

All-cause mortality according to transplant status among waitlisted patients with end-stage renal disease (ESRD) due to granulomatosis with polyangiitis

	N	Total follow-up	Deaths	Mortality rate (/1000 patient-years, 95% CI)	unadjusted RR (95% CI)	Age-adjusted, sex-adjusted, enrolment-adjusted RR (95% CI)*	Fully adjusted RR (95% CI)†
Overall	1525	10 456	438	41.9 (38.1 to 46.0)
Transplanted	946	6804	199	29.3 (25.5 to 33.6)	0.39 (0.33 to 0.46)	0.30 (0.25 to 0.36)	0.30 (0.25 to 0.36)
Not transplanted	579	3651	239	65.5 (57.7 to 74.3)	Ref	Ref	Ref
Age
<40 years	448	3481	71	20.4 (16.2 to 25.7)
Transplanted	344	2816	39	13.9 (10.1 to 19.0)	0.32 (0.20 to 0.50)	0.22 (0.14 to 0.35)	0.19 (0.12 to 0.31)
Not transplanted	104	666	32	48.1 (34.0 to 68.0)	Ref	Ref	Ref
40–49 years	284	2119	75	35.4 (28.2 to 44.4)
Transplanted	188	1453	35	24.1 (17.3 to 33.6)	0.33 (0.22 to 0.52)	0.22 (0.14 to 0.37)	0.25 (0.15 to 0.41)
Not transplanted	96	667	40	60.0 (44.0 to 81.8)	Ref	Ref	Ref
50–59 years	407	2723	130	47.7 (40.2 to 56.7)
Transplanted	232	1679	57	34.0 (26.2 to 44.0)	0.43 (0.31 to 0.60)	0.23 (0.16 to 0.34)	0.21 (0.14 to 0.32)
Not transplanted	175	1045	73	69.9 (55.5 to 87.9)	Ref	Ref	Ref
≥60 years	417	2302	168	73.0 (62.7 to 84.9)
Transplanted	213	1256	74	58.9 (46.9 to 74.0)	0.62 (0.47 to 0.82)	0.35 (0.26 to 0.48)	0.38 (0.27 to 0.52)
Not transplanted	204	1046	94	89.9 (73.4 to 110.0)	Ref	Ref	Ref
Sex
Male	923	6268	274	43.7 (38.8 to 49.2)
Transplanted	577	4292	127	29.6 (24.9 to 35.2)	0.38 (0.31 to 0.48)	0.28 (0.23 to 0.36)	0.30 (0.23 to 0.37)
Not transplanted	346	1976	147	74.4 (63.3 to 87.5)	Ref	Ref	Ref
Female	633	4358	170	39.0 (33.6 to 45.3)
Transplanted	400	2911	78	26.8 (21.5 to 33.5)	0.39 (0.29 to 0.51)	0.33 (0.25 to 0.45)	0.33 (0.24 to 0.45)
Not transplanted	233	1447	92	63.6 (51.8 to 78.0)	Ref	Ref	Ref
Calendar year of ESRD onset*
1995–2004	560	2217	96	43.3 (35.5 to 52.9)
Transplanted	347	1290	25	19.4 (13.1 to 28.7)	0.16 (0.10 to 0.27)	0.16 (0.10 to 0.26)	0.17 (0.10 to 0.29)
Not transplanted	213	897	71	79.1 (62.7 to 99.9)	Ref	Ref	Ref
2005–2014	890	4230	121	28.6 (23.9 to 34.2)
Transplanted	478	2097	27	12.9 (8.8 to 18.8)	0.24 (0.16 to 0.37)	0.25 (0.16 to 0.38)	0.25 (0.16 to 0.38)
Not transplanted	412	2121	94	44.3 (36.2 to 54.3)	Ref	Ref

^*Excluded patients who were not waitlisted prior to the end of time period censoring.

^†Fully adjusted models adjust for sex, age, ESRD year, comorbidity score, white/non-white, first modality. RR. relative risk.