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. 2018 Dec 7;27(2):394–410. doi: 10.1016/j.ymthe.2018.11.019

Figure 3.

Figure 3

Overexpression of lncRNA-ORLNC1 Results in Osteoporosis and Impairs Osteogenic Capacity in a Mouse Model of Osteoporosis

(A and B) lncRNA-ORLNC1 expression was markedly upregulated in the bone tissue (A) and BMSCs (B) from lncRNA-ORLNC1-overexpressing transgenic mice. WT, wild-type mice; TG, transgenic mice. (C and D) Representative μCT images (C) and quantitative analysis (D) of the femur from WT and TG mice indicated the bone loss of TG mice compared to WT mice. WT + OVX, wild-type mice with OVX surgery; TG + OVX, transgenic mice with OVX surgery. (E) The mRNA levels of ALP, Bmp4, Bglap, Spp1, and Col1a1 in the bone tissue of TG mice compared with WT mice. (F and G) ARS (F) and ALP (G) stainings exhibited impaired osteogenic differentiation potential of BMSCs in TG mice and TG mice with OVX surgery. Scale bar, 100 μm. *p < 0.05, **p < 0.01, and ***p < 0.001.