Figure 3.

SOX4 Transcript Levels in the Developing and Adult Human Brain

(A–C) Changes in SOX4 expression levels during development and adult life in the dorsolateral prefrontal cortex, striatum, and cerebellar cortex, as assessed by RNA-seq. The first three samples were obtained during the three trimesters of fetal development, and the next three during the first four decades of life, as indicated on the x axis. No data were available for the cerebellar cortex in the first trimester of embryogenesis.

(D) RNA microarray data demonstrating that SOX4 expression is significantly higher in neuroanatomical regions with high-level neurogenesis (ventricular and subventricular zones) than in regions with low-level neurogenesis (subplate and cortical plate) at 21 weeks of gestation (Mann-Whitney U-test, p < 0.01).

Error bars in the standard box plots from PASW/SPSS represent the interquartile range.