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. 2019 Jan 27;2019:1648919. doi: 10.1155/2019/1648919

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Copyright © 2019 Yu Mao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Attenuation of effects of postinjected HDACIs on thermal hyperalgesia in rats. Rat received injection of HDACI or vehicle (arrows show the time of injection) at the indicated dose after unilateral intraplantar injection of CFA. PWL was determined before CFA injection as a baseline and after CFA injection as hyperalgesia response. SAHA (a), TSA (b), LAQ824 (c), sodium butyrate (d), 4-PBA (e), VPA (f), and MS-275 (g) were injected for the panel (in parenthesis). Inhibition of hyperalgesia by all HDACIs was calculated by two-way ANOVA. Data show PWL as the mean ± SEM for the ipsilateral paw (^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 compared with vehicle-treated rats at the same time point).