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. 2018 Dec 6;27(2):442–455. doi: 10.1016/j.ymthe.2018.11.017

Figure 2.

Figure 2

TGF-β1 Alters the Bronchial Epithelial MicroRNAome

(A) Volcano plot of the altered miRNA expression profile of primary NHBE ALI cultures treated with TGF-β1. Primary bronchial epithelial cultures redifferentiated at the ALI were treated with TGF-β1 (10 ng/mL) or vehicle (as control) as described by us earlier.15 TGF-β-mediated changes in miRNA expression profile in NHBE ALI cultures were determined using Exiqon microRNA Human panel I and II, v.4 (Exiqon, Woburn, MA, USA). Data were analyzed using the GenEX software. (B) TGF-β1 shows statistically significant (p < 0.05) Log2-fold change in the expression of 62 miRNAs. Green, downregulated miRNAs; red, upregulated miRNAs. n = 3 different lungs. Arrow indicates the position of miR-145-5p.