Figure 1.

miR-621 Had Lower Expression in HCC Tissues and Cells, and a Low Expression of miR-621 Was Associated with Poor Survival in HCC

(A) Validation of the 10 most upregulated miRNAs in HCC from 20 HCC tumor and adjacent nontumor tissues was measured by real-time qPCR. (B) Validation of the seven most downregulated miRNAs in HCC from 20 HCC tumor and adjacent nontumor tissues was measured by real-time qPCR. (C) The expression of miR-621 in HCC tumor and matched nontumor tissues of 50 patients was detected using real-time qPCR. (D) Kaplan-Meier curve for TCGA datasets of 327 HCC patients. (E) Kaplan-Meier curve for an independent set of 90 HCC patients. (F) miR-621 expression in the human HCC lines HepG2, Smmc-7721, and Bel-7404 and the normal liver cell line LO2 was detected by real-time qPCR. *p < 0.05, **p < 0.01, ***p < 0.001.