Table 1.

Overview of insulin accumulation in the CNS following various delivery routes.

Delivery Route	Insulin Concentration	Region	Time	Reference
IV	0.045 %inj/g	Whole brain	2 min	Banks et al 1997b
ICV	0.24 mg/g	Olfactory Bulb	60 Min	Aime et al 2012
INL	0.265 %inj/g	Hypothalamus	30 min	Rhea et al 2017
Ocular	0.24 pg insulin/μg protein	Thalamus	10 min	Koevary et al 2003