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. 2019 Feb 4;9:3110. doi: 10.3389/fimmu.2018.03110

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Copyright © 2019 Tjitro, Campbell, Basova, Johnson, Najera, Lindsey and Marcondes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn's diagram showing transcription factors with frequent binding motifs among genes with significant changes in RNA Pol II recruitment, immediately following the stimulation of THP1 cells with HIV-1 Tat, Meth, or both together. Matrices for transcription factor binding motifs were generated from ChIP-seq data. For that, SICER raw data in BED format was loaded into TRANSFAC, and the Match-algorithm, was applied as binding factor identifier. Transcription factors with highest frequency of binding motifs in gene promoters affected by HIV-1 Tat, Meth, or both together were estimated. The transcription factors listed in each segment of the Venn's diagram are all significantly increased in comparison to control conditions, and are ranked in order according to frequency matrices, from highest on top to lowest at the bottom of the segregated lists.