Fig. 3. Relationship between sensitivity, affinity and position of the fluorinated group. (a) Correlation between C2 and the respective pKD of all the spy molecules where the affinity could be estimated, highlighting the regions where the sensitivity of the spy molecules decays considerably. Dashed circles display molecules with similar pKD that possess different C2 due to the variation in the fluorine attachment. The same plot was also made for the aromatic series A (b) and B (c), where the trend of an ideal intermediate affinity can be observed.
