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Stereo-selectivity is afforded by electrostatic repulsion. The amide plane of substrate is shown as gray dash. (A and B) In AgcS both alanine enantiomers fit equally well as the two faces of the binding pocket are hydrophobic. (C) In LeuT, which only binds l-amino acids, one face is hydrophobic while the other is polarized ensuring selection for l-amino acids over d-amino acids.
