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CD8+ T cells infiltrating the spinal cord of ALS mice show a restricted T cell receptor repertoire. (A) Comparison of CDR3-LD (polyclonal, oligoclonal, or monoclonal distribution) of TRBV families in CD8+ T cells isolated from LNs (peripheral) and CNS (infiltrated) of 150-d-old SOD1G93A mice (n = 6). (B) Distribution of the mTRBV15 CDR3 length across the CD8+ T cell infiltrating the CNS shared among four mice (each color corresponding to one mouse).
