Table 5.

Cox regression: univariate/multivariate analysis

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	P-value	HR	95% CI	P-value
T stage	12.742	3.684–44.07	0.000***	20.946	4.459–43.10	0.001**
ISUP						0.426
ISUP (1)	0.359	0.017–4.331	0.356	0.077	0.003–2.020	0.124
ISUP (2)	0.497	0.051–4.833	0.547	0.113	0.005–2.429	0.164
ISUP (3)	3.670	0.435–30.93	0.232	0.151	0.005–4.717	0.282
P for trend			0.009**
Conjoint analysis the expression of Nrf2 in ccRCC and normal tissues	5.043	1.454–17.49	0.011*	1.697	0.197–14.63	0.631
Conjoint analysis the expression of HO-1 in ccRCC and normal tissues	7.505	1.681–34.41	0.008**	4.333	0.360–52.18	0.248
Perirenal fatty invasion	5.066	1.337–19.20	0.017*
Necrosis	3.291	1.000–10.83	0.013*
Sarcomatoid differentiation	7.872	2.389–25.94	0.001**
Nrf2 expressed in ccRCC	3.283	0.977–11.03	0.055
HO-1 expressed in ccRCC	7.390	0.919–59.44	0.060
Intravenous tumor thrombus	1.185	0.150–9.350	0.872
Fiber capsule invasion	2.132	0.622–7.315	0.229

Note:

^*P<0.05;

^**P<0.01;

^***P<0.001.

Abbreviation: ccRCC, clear cell renal cell carcinoma; ISUP, International Society of Urological Pathology.