Table 2.
CCR4 expression in subtypes of non-Hodgkin lymphoma
| Histology | Study/reference | CCR4+ (%) | CCR4+ (N/N total) | Method |
|---|---|---|---|---|
|
| ||||
| MF | Jones et al (2000)49 | 14 | 1/7 | IHC |
| MF | Kallinich et al (2003)42 | 92 | 11/12 | IHC |
| MF | Yagi et al (2006)43 | 54 | 14/26 | IHC |
| Transformed MF | Jones et al (2000)49 | 100 | 5/5 | IHC |
| Transformed MF | Ishida et al (2004)44 | 41 | 7/17 | IHC |
| MF and SS | Ferenczi et al (2002)48 | 100 | 11/11 | FC |
| MF and SS | Sugaya et al (2015)45 | 57 | 13/23 | IHC |
| MF and SS | Duvic et al (2012, 2015)46,55 | 89 | 31/35 | FC and IHC |
| MF and SS | Kim et al (2018)36 | 97 | 280/290 | IHC |
| SS | Narducci et al (2006)39 | 100 | 12/12 | FC |
| SS | Yagi et al (2006)43 | 100 | 5/5 | IHC |
| MF, SS, or PTCL | Ogura et al (2014)50 | 78 | 50/64 | IHC |
| ATLL | Yoshie et al (2002)52 | 92 | 22/24 | RT-PCR |
| ATLL | Ishida et al (2004)53 | 88 | 91/103 | FC |
| ATLL | Phillips et al (2016)51 | 91 | 65/71 | FC and IHC |
| ALCL | Jones et al (2000)49 | 73 | 8/11 | IHC |
| ALCL | Yagi et al (2006)43 | 100 | 5/5 | IHC |
| PTCL, NOS | Ishida et al (2004)44 | 38 | 19/50 | IHC |
| PTCL, NOS | Jones et al (2000)49 | 27 | 4/15 | IHC |
| AITL | Ishida et al (2004)44 | 35 | 8/23 | IHC |
| DLBCL | Nakayama et al (2013)47 | 13 | 10/80 | IHC |
Abbreviations: AITL, angioimmunoblastic T-cell lymphoma; ALCL, anaplastic large cell lymphoma; ATLL, adult T-cell leukemia/lymphoma; CCR4, chemokine receptor type 4; DLBCL, diffuse large B-cell lymphoma; FC, flow cytometry; IHC, immunohistochemistry; MF, mycosis fungoides; NOS, not otherwise specified; PTCL, peripheral T-cell lymphoma; SS, Sézary syndrome.