3.2. Analysis.

Comparison 3 COCP versus LNG IUS, Outcome 2 MBL change from baseline to end of treatment (12 months).

MBL change from baseline to end of treatment (12 months)
Study	Comparison	N	Results	Conclusion/comment
Endrikat 2009	COCP (20 ug ethinyl oestradiol + 1 mg norethindrone acetate) versus LNG IUS	Total: N = 42 FAS (full analysis set): N = 39 (19 in COCP group and 20 in LNG IUS group)	Median change from baseline (IQR) MBL COCP: ‐182 (‐244 to ‐105) LNG IUS: ‐214 (‐308 to ‐102)	P = 0.0024 (LNG IUS compared to COCP)
Shabaan 2011	COCP (30 mcg ethinyl oestradiol + 150 mcg levonorgestrel) versus LNG IUS	Total: N = 112 At 12 months, only N = 64 had alkaline haematin assessment)	Alkaline haematin mean (SD) (change from baseline): COCP: 154.8 (159.7) LNG IUS: 251.7 (136.7)	t test (LNG IUS compared to COCP), P = 0.007