3.3. Analysis.

Comparison 3 COCP versus LNG IUS, Outcome 3 Percentage change in MBL (from baseline to end of study).

Percentage change in MBL (from baseline to end of study)
Study	Comparison	N	Results	Conclusion/comment
Endrikat 2009	COCP (20 ug ethinyl oestradiol + 1 mg norethindrone acetate) versus LNG IUS	Total: N = 42 FAS (full analysis set): N = 39 (19 in COCP group and 20 in LNG IUS group)	Mean percentage change COCP: ‐68% LNG IUS: ‐83% No measure of variation reported	Authors concluded that LNG IUS was associated with a significantly greater percentage change from baseline than COCP (P = 0.0024). Estimate for median difference between the 2 interventions: ‐62 (95% CI ‐89 to ‐18).
Shabaan 2011	COCP (30 mcg ethinyl oestradiol + 150 mcg levonorgestrel) versus LNG IUS	Total: N = 112 At 12 months, only N = 64 had alkaline haematin assessment At 12 months, only N = 64 had PBAC assessment	Mean (SD) percentage change from baseline: Alkaline haematin: COCP: 35.0 (77.0) LNG IUS: 87.4 (11.3) PBAC: COCP: 2.5 (93.2) LNG IUS: 86.6 (17.0)	Alkaline haematin: P = 0.013 PBAC: P < 0.001