(A) A patient with epilepsy of unknown etiology and no features suggestive of any particular genetic etiology can choose 4 individual tests: no genetic testing, CMA, EP, and WES. (B) A patient with epilepsy of unknown etiology and no features suggestive of any particular genetic etiology can choose 7 testing strategies: no genetic testing, CMA ± EP ± WES, CMA ± WES ± EP, EP ± CMA ± WES, EP ± WES ± CMA, WES ± CMA ± EP, and WES ± EP ± CMA. CMA = chromosomal microarray; EP = epilepsy panel; WES = whole-exome sequencing.