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. Author manuscript; available in PMC: 2019 Feb 11.
Published in final edited form as: Biol Psychiatry. 2017 Jul 21;83(1):50–60. doi: 10.1016/j.biopsych.2017.06.034

Figure 6. RAGE deletion attenuates CUS induced behavioral deficits in mice.

Figure 6.

(A) Experimental paradigm. Wild type (WT) and RAGE deletion mutant mice were tested for (B) sucrose consumption (main effect of stress F(1,33)=11.39, p=0.0019; no interaction of stress and genotype) and (C) water consumption (no effect F(1,33)=0.0806, p=0.7783 ). Mice were tested for (D) novel object recognition 24h after familiar object exposure (interaction of stress and genotype F(1,15)=4.853, p=0.0437). (E) Total cage locomotor activity within a 20 min period (no effect F(1,30)=0.1782, p=0.6759). The results are expressed as the mean ± SEM. N=6–10 animals per group. (F) Experimental paradigm for disulfide HMGB1 (dsHMGB1) infusion in naïve C57BL6 mice. (G) Mice were tested for sucrose preference 4 hrs post dsHMGB1 ICV infusion (t(24)=4.399, p=0.0002). The results are expressed as the mean ± SEM. N=12–14 animals per group. *p<0.05 and ***p<0.001. Two-way ANOVA was performed followed by Bonferroni post hoc test for behavioral analysis in RAGE KO mice. Student t-test was performed for sucrose preference test following dsHMGB1 infusion.