NCT00152854.

Methods	Randomised, double‐blind, placebo‐controlled, cross‐over study Treatment for 7 days, then cross‐over
Participants	Ambulatory cancer patients, established opioid regimen of > 60 mg/day of morphine equivalents Exclude: severe pain; radiotherapy within 6 weeks; started chemo or hormone therapy within 4 weeks; change to NSAID or corticosteroid medication within 1 week or during study; contraindication to or use of paracetamol within 2 days N = 12 M and F eligible No baseline pain requirement reported, other than participants with no pain were excluded
Interventions	In addition to established opioid regimen: Paracetamol 4 x 1000 mg daily Placebo
Outcomes	PI: 0 to 10 NRS (daily, and weekly questionnaires) Preference for treatment period
Notes	Vardy J (Principal Investigator) Study started July 2005, completed December 2012 No results posted 30 March 2017